Statistical mechanics of protein folding by cluster distance geometry
نویسندگان
چکیده
منابع مشابه
Statistical mechanics of protein folding by cluster distance geometry.
This is our second type of model for protein folding where the configurational parameters and the effective potential energy function are chosen in such a way that all conformations are described and the canonical partition function can be evaluated analytically. Structure is described in terms of distances between pairs of sequentially contiguous blocks of eight residues, and all possible conf...
متن کاملRecognizing protein folds by cluster distance geometry.
Cluster distance geometry is a recent generalization of distance geometry whereby protein structures can be described at even lower levels of detail than one point per residue. With improvements in the clustering technique, protein conformations can be summarized in terms of alternative contact patterns between clusters, where each cluster contains four sequentially adjacent amino acid residues...
متن کاملStatistical mechanics of protein folding by exhaustive enumeration.
It is hard to construct theories for the folding of globular proteins because they are large and complicated molecules having enormous numbers of nonnative conformations and having native states that are complicated to describe. Statistical mechanical theories of protein folding are constructed around major simplifying assumptions about the energy as a function of conformation and/or simplifica...
متن کاملStatistical Mechanics Model for Protein Folding
We present a novel statistical mechanics formalism for the theoretical description of the process of protein folding↔unfolding transition in water environment. The formalism is based on the construction of the partition function of a protein obeying two-stage-like folding kinetics. Using the statistical mechanics model of solvation of hydrophobic hydrocarbons we obtain the partition function of...
متن کاملJohn von Neumann Institute for Computing Cluster Distance Geometry and Protein Folding
c © 2006 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...
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ژورنال
عنوان ژورنال: Biopolymers
سال: 2004
ISSN: 0006-3525,1097-0282
DOI: 10.1002/bip.20118